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How Does Växamine Advanced™ Work?
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| Växamine Advanced™ uses a proprietary blend of synergistic ingredients to provide the highest possible level of anti-inflammatory properties. Utilizing a patented extraction process we are able to use “Bio-Chemical Specific Plant Extracts” to formulate highly effective nutriceutical compounds. One such extract comes from the hops plant. This natural extract is a highly selective inhibitor of two enzymes that cause inflammation (enzymes COX-2 & 5-LOX). These enzymes change arachidonic acid into pro-inflammatory leukotrienes which are then used by the body to create inflammation and pain. Our unique hops extract is so effective that in a human oral dosing clinical study it outperformed Celebrex® as a COX-2 inhibitor and was more selective than Vioxx®. This means that Växamine Advanced™ selectively inhibits COX-2 while leaving COX-1 virtually untouched. This is extremely important because COX-1 is involved in the production of prostaglandins that are vital to the health of the gastrointestinal and cardiovascular systems. Now you can get the results that you would expect from a drug but without the concerns of side-effects. Simply put, Växamine Advanced™ is very potent yet gastro and cardio friendly. |
Inflammatory Cycle
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It is well documented that the COX pathway generates inflammatory prostaglandins, but medical research has largely ignored the
potentially damaging effects of 5-LOX, the enzyme that forms the second branch of the dual arachidonic acid inflammation
pathways.
5-LOX generates inflammatory leukotrienes, which are known to be potent inflammatory mediators that play a role in pain and allergic reactions. They may also play a role in ischemia and atherosclerosis. Stroke, traumatic brain injury, and Alzheimer's disease have also been linked to the activity of 5-LOX and leukotrienes. The results of a recent study indicate that blocking COX-2 while ignoring the effects of 5-LOX may be counter-productive. In fact, using COX-2 inhibitors to block the activity of COX-2 may actually cause 5-LOX levels to increase further, making inflammation worse, rather than better. This "rebound" inflammation is evidently caused by shifting arachidonic acid toward synthesis of damaging leukotrienes through the 5-LOX pathway. In one 5-LOX inhibition study, researchers speculated, ‘Inhibitors of the two pathways might have additive, or even synergistic neuroprotective effects when used in combination.' By study's end, they had concluded that a 5-LOX inhibitor " significantly potentiated the effects of three different COX inhibitors." Their findings suggest, quite simply, that while anti-inflammatory therapy with COX-inhibitors may be neuroprotective , therapy combining both COX and 5-LOX inhibitors should prove considerably more effective. This is one reason why we formulated Växamine Advanced™ to inhibit 5-LOX. You can feel confident knowing that clinical studies have found Växamine Advanced™ to be both effective and safe. |
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